SLEDAI-2K (SLE Disease Activity Index 2000)

Quantifies systemic lupus erythematosus disease activity by summing 24 weighted clinical and laboratory descriptors into an activity band, to monitor flares and guide treat-to-target management, presupposing an established SLE diagnosis — not a diagnostic test.

Seizure (recent onset; exclude metabolic/infectious/drug) (+8)

Psychosis (exclude uremia/drug) (+8)

Organic brain syndrome (exclude metabolic/infectious/drug) (+8)

Visual disturbance (retinal/optic changes of SLE) (+8)

Cranial nerve disorder (new sensory/motor neuropathy) (+8)

Lupus headache (severe, persistent, narcotic-nonresponsive) (+8)

Cerebrovascular accident (CVA; new onset, exclude arteriosclerosis) (+8)

Vasculitis (ulceration/gangrene/nodules/infarct, or biopsy/angiogram) (+8)

Arthritis (≥2 joints with pain and inflammation) (+4)

Myositis (proximal weakness with raised CPK/aldolase, EMG, or biopsy) (+4)

Urinary casts (heme-granular or RBC casts) (+4)

Hematuria (>5 RBC/hpf; exclude stone/infection) (+4)

Proteinuria (new/recurrent/persistent >0.5 g/24h) (+4)

Pyuria (>5 WBC/hpf; exclude infection) (+4)

Rash (inflammatory, new OR persistent) (+2)

Alopecia (patchy/diffuse, new OR persistent) (+2)

Mucosal ulcers (oral/nasal, new OR persistent) (+2)

Pleurisy (pleuritic pain with rub/effusion/thickening) (+2)

Pericarditis (pain with rub/effusion/ECG or echo) (+2)

Low complement (decreased CH50, C3, or C4) (+2)

Increased DNA binding (>25% by Farr, or above lab normal) (+2)

Fever (>38 C; exclude infection) (+1)

Thrombocytopenia (<100,000 platelets/mm3) (+1)

Leukopenia (<3,000 WBC/mm3; exclude drug) (+1)