2019 EULAR/ACR SLE Classification Criteria

Applies the 2019 EULAR/ACR ANA-entry-gated weighted criteria across ten organ and immunology domains to classify systemic lupus erythematosus, for research/cohort definition, not a diagnostic test.

ANA ≥ 1:80 on HEp-2 (or equivalent positive assay), ever

Constitutional domain (highest item met)

Hematologic domain (highest item met)

Neuropsychiatric domain (highest item met)

Mucocutaneous domain (highest item met)

Serosal domain (highest item met)

Musculoskeletal domain (highest item met)

Renal domain (highest item met)

Antiphospholipid antibodies (anticardiolipin OR anti-β2GP1 OR lupus anticoagulant)

Complement proteins (low C3 / low C4)

SLE-specific antibodies (anti-dsDNA OR anti-Smith)