RESP Score (Respiratory ECMO Survival Prediction)

Estimates in-hospital survival for adults started on ECMO (predominantly veno-venous) for severe acute respiratory failure, from twelve pre-ECMO variables; a population-level prognostic aid derived in a respiratory-failure ECMO cohort — not an individual treatment-eligibility, triage, or withdrawal criterion.

Age

Immunocompromised (hematologic malignancy, solid tumor, transplant, HIV, or cirrhosis)

Duration of mechanical ventilation before ECMO (shorter scores higher)

Acute respiratory diagnosis (primary, single-select)

CNS dysfunction (neurotrauma, stroke, encephalopathy, cerebral embolism, seizure)

Acute associated (nonpulmonary) infection

Neuromuscular blockade before ECMO

Nitric oxide use before ECMO

Bicarbonate infusion before ECMO

Cardiac arrest before ECMO

PaCO₂ ≥75 mmHg (inclusive at 75 mmHg)

Peak inspiratory pressure ≥42 cmH₂O (inclusive at 42 cmH₂O)