PLASMIC Score for TTP

Sums seven bedside components to estimate the pretest probability of severe ADAMTS13 deficiency (TTP) in adults with thrombotic microangiopathy, supporting the urgent decision to start plasma exchange before assay results return; a low or intermediate score does not exclude TTP.

Platelet count (x10&sup9;/L)

Hemolysis variable (reticulocyte > 2.5%, OR undetectable haptoglobin, OR indirect bilirubin > 2.0 mg/dL)

Active cancer (cancer treatment within the preceding 12 months)

History of solid-organ or stem-cell transplant

MCV (fL)

INR

Creatinine (mg/dL)