HScore for Reactive Hemophagocytic Syndrome (HLH)

Estimates the probability of reactive haemophagocytic syndrome (HLH) in a patient with a suspicious clinical picture by summing nine weighted clinical and laboratory variables into the HScore, for diagnostic likelihood assessment.

Known underlying immunosuppression (HIV+ or long-term immunosuppressive therapy)

Temperature (°C)

Organomegaly

Number of cytopenias (Hb ≤ 9.2 g/dL, WBC ≤ 5,000/mm³, and/or platelets ≤ 110,000/mm³)

Ferritin (ng/mL)

Triglyceride (mmol/L)

Fibrinogen (g/L)

AST / SGOT (U/L)

Hemophagocytosis on bone marrow aspirate