Five-Factor Score (FFS) for Systemic Necrotizing Vasculitis

Prognostic score for systemic necrotizing vasculitides (PAN, MPA, EGPA/Churg-Strauss, GPA/Wegener) — prognostic only, not a diagnostic or standalone treatment-decision rule; two non-interchangeable versions exist (original 1996 and revised 2009), so select the one your protocol uses.

FFS version

Serum creatinine (must be > 0)

Creatinine unit

Age (years) — scored only in the 2009 version (age > 65)

Proteinuria > 1 g/day (1996 factor only)

Cardiac involvement / cardiac insufficiency (both versions, +1)

Severe gastrointestinal (GI) involvement — bleeding, perforation, infarction, or pancreatitis (both versions, +1)

Central nervous system (CNS) involvement (1996 factor only)

ENT (otorhinolaryngeal) manifestations present (2009 only; reverse-coded: absence = +1)