DIPSS / DIPSS-Plus (Primary Myelofibrosis Prognosis)

Two-stage prognostic estimate for primary myelofibrosis that grades the dynamic clinical (DIPSS) risk category, then refines it with platelet count, transfusion status, and karyotype, reporting both categories together.

Age (years)

White blood cell count (×10⁹/L)

Hemoglobin (g/dL)

Peripheral blood blasts (%)

Constitutional symptoms (weight loss / fever / night sweats)

Platelet count below 100 ×10⁹/L

Red cell transfusion need / dependence

Unfavorable karyotype (complex; or sole/two abnormalities incl. +8, -7/7q-, i(17q), -5/5q-, 12p-, inv(3), 11q23; normal, sole 13q-, sole 20q- = favorable)