CLL-IPI (International Prognostic Index for CLL)

Weighted prognostic index for chronic lymphocytic leukemia combining TP53 status, IGHV mutational status, beta-2 microglobulin, clinical stage, and age into four risk groups to stratify overall survival and time to first treatment, as relative risk only.

TP53 abnormal — del(17p) and/or TP53 mutation (+4, dominant)

IGHV mutational status — unmutated (+2)

Serum beta-2 microglobulin > 3.5 mg/L (+2, strict cutoff)

Clinical stage — advanced (Binet B–C or Rai I–IV) (+1)

Age > 65 years (+1, strict cutoff)