Cairo-Bishop Tumor Lysis Syndrome (TLS) Criteria & Grade

Classifies and grades tumor lysis syndrome in patients on cytotoxic therapy from four metabolic abnormalities (uric acid, potassium, phosphorus, calcium) plus renal, cardiac, and neurologic criteria, using the original Cairo–Bishop 2004 definition rather than the stricter Howard modification.

Patient type (sets the phosphorus threshold)

Uric acid (mg/dL)

Uric acid increased ≥ 25% from baseline?

Potassium (mEq/L)

Potassium increased ≥ 25% from baseline?

Phosphorus (mg/dL)

Phosphorus increased ≥ 25% from baseline?

Calcium, corrected/total (mg/dL)

Calcium DECREASED ≥ 25% from baseline?

Serum creatinine as a multiple of ULN (x ULN, NOT raw mg/dL)

Cardiac arrhythmia severity (CTCAE-style)

Seizure severity (CTCAE-style; no grade-1 level)

Death attributable to TLS?